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一種針對(duì)多粘菌素耐藥菌特異性治療候選輔助藥物

成果領(lǐng)域: 現(xiàn)代農(nóng)業(yè)

推廣方式:

成果歸屬企業(yè): 吉林大學(xué)汽車動(dòng)物醫(yī)學(xué)學(xué)院鄧旭明教授科研團(tuán)隊(duì)

成果鑒定時(shí)間:

成果介紹

針對(duì)全世界范圍廣泛流行的mcr-1及攜帶菌的多粘菌素耐藥性問題，進(jìn)行長(zhǎng)期和大量的天然化合物抑制劑篩選，發(fā)現(xiàn)以MR1033為代表的多種化合物可恢復(fù)多粘菌素對(duì)不同來源攜帶mcr-1大腸桿菌的敏感性，協(xié)同作用明顯（FIC index=O.156-0.188）。在小鼠腹腔感染和肺部感染模型中顯著提高多粘菌素B的治療率。

成果應(yīng)用案例介紹

聯(lián)系方式

電話/微信: 13822630888

相關(guān)成果

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000011s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001300s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000024s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000246s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000197s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000028s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000014s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000030s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000229s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'index', 1 => 'results', 2 => 'views', ), )
[ HEADER ] array ( 'host' => 'www.heilongjiangxuexiang.com', 'user-agent' => 'Mozilla/5.0 (Windows NT 10.0; WOW64; Trident/7.0; rv:11.0) like Gecko', 'referer' => 'http://www.baidu.com', 'cookie' => 't=92d7540e476b153862b4ea2356ede7b3; r=8148', 'accept-language' => 'zh-CN,zh', 'accept-encoding' => 'gzip, deflate', 'accept' => 'text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8', 'content-type' => 'application/x-www-form-urlencoded; Charset=UTF-8', 'connection' => 'Keep-Alive', 'content-length' => '', )
[ PARAM ] array ( 'ids' => '4551', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000689s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000125s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000018s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @upload_config_init [ RunTime:0.000373s ]
[ BEHAVIOR ] Run \addons\editpage\Editpage @config_init [ RunTime:0.000030s ]
[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000021s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000026s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000030s ]

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